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Schematic representation of a Self-assembled Multifunctional Dendrimer

The long term goal of this project is to develop a variety of multi-functional nanostructured materials for biomedical applications. Short-term, we intend to enhance our understanding of the fundamental principles that modulate the self-assembly of guanine derivatives into functional nanostructures such as dendrimers. These studies will reveal important fundamental knowledge on the principles and rules that allow the self-assembly (and disassembly) of guanine derivatives into multifunctional dendrimers. The research builds on recent discoveries from our laboratory on how the self-assembly properties of 8ArGs can be modulated by the nature of a group attached to the C8 of the guanine base.